Current mass vaccination can lead to mass die-off of the vaccinated by ADE: Vanden Bossche

Narrow vaccine targeting of the spike protein and mass vaccinating during a pandemic are a potential setup for disaster

“I am truly afraid these dynamics will eventually allow for the natural selection of individuals with uncompromised innate immunity [i.e., the unvaccinated] while eliminating those without it [i.e., the vaccinated].” G. Vanden Bossche

Virologist Geert Vanden Bossche describes how current Covid mass vaccination will continue to promote natural selection of infectious viral variants that escape vaccinal antibodies and can kill billions of vaccinated people by antibody-dependent enhancement (ADE) of infection by future variants.

Vaccinal antibodies narrowly targeting the viral spike protein and that neutralized a previous variant can become enhancing of infection by new variants. This is ADE.

We’ve already seen how the ratio of neutralizing to potentially infection-enhancing vaccinal antibodies is lower for the Delta variant than for the original Wuhan strain, whose spike protein current vaccines exclusively target.

Now that ratio has dropped further for Omicron compared to Delta. Fewer neutralizing antibodies, more enhancing ones. This process will only continue as new variants are evolutionarily pressured to escape neutralizing vaccinal antibodies.

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Mass vaccination promotes viral resistance to C-19 vaccines. Viral resistance drives enhanced infectiousness of SARS-CoV-2 (e.g., Omicron) and may ultimately enable SARS-CoV-2 to utilize alternative cell surface determinants to enter permissive cells.

I am convinced that sustained suboptimal immune pressure will ultimately lead to allosteric mutations of S [spike] protein. Such mutation(s) would not prevent neutralizing Abs [antibodies] from binding to S protein but alter the receptor-binding domain (RBD) in ways that enable domains not recognized by these neutralizing Abs to bind to alternative receptor molecules on permissive host cells.

Would such allosteric mutation prevent the virus from binding to ACE2? Maybe, or maybe not.

Such alternate SARS-CoV-2 spike protein-binding receptors have been recently discovered, including sialated glycans, which mediate viral entry into cells.

It has been well documented that receptor-mediated entry of SARS-CoV-2 is not limited to ACE2. At any rate, this mechanism would no longer allow previously neutralizing Abs acquired upon vaccination or recovery from natural disease to neutralize the virus, but still enable their binding to it.

Abs that are still capable of binding to the virus without neutralizing it are at risk of causing Ab-dependent enhancement of disease (ADE).

Even though the intrinsic virulence of the virus is unlikely to change (as there is no evidence of immune pressure being placed on virulence genes), the occurrence of ADE would have the same effect because it enhances and accelerates viral pathogenicity.

When this happens, we’re likely to generate a situation that resembles the one described for Marek’s disease [in chickens], although using a different pathway to cause devastating disease.

Whereas Marek’s virus is so virulent that it breaks through the innate immune defense of the host (poultry) and stays ahead of protective adaptive immunity in unvaccinated chicken, an allosteric SARS- CoV-2 variant would not only break through the innate immune response of vaccinees (due to vaccine- mediated suppression of relevant innate Abs) and resist vaccinal Abs (by bypassing traditional receptor domains within ACE2), but also become more pathogenic due to ADE.

It is undeniable that mass vaccination will only drive the virus to fully exploit its evolutionary capacity, including – if needed – its ability to use alternate receptor domains on permissive cells.

The fitness cost [to the virus] that may come with such a dramatic mutation is likely to be rewarded with enhanced pathogenicity [by ADE in the vaccinated].

I am truly afraid these dynamics will eventually allow for the natural selection of individuals with uncompromised innate immunity [i.e., the unvaccinated] while eliminating those without it [i.e., the vaccinated].

While such natural selection would lead to an eradication of SARS-CoV-2 as innate immunity [in the unvaccinated] sterilizes the virus and blocks transmission, the consequences would be unimaginable – the price paid for ending the pandemic by virus eradication is not comparable to the one paid for by generating herd immunity [by natural infection in the unvaccinated] and allowing the virus to enter an endemic state.

Those who are enforcing mass vaccination are opting for the former [natural selection of the unvaccinated] instead of the latter [herd immunity through natural infection], an act that will be remembered as the deadliest sin ever.

Source: https://www.voiceforscienceandsolidarity.org/scientific-blog/mass-vaccination-will-push-sars-cov-2-spike-protein-beyond-omicron

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