High blood pressure after the jab might be explained by spike protein binding of ACE2 and a consequent increase in angiotensin II, a powerful vasoconstrictor (Updated 8/19/22)
According to this hypothesis, long term use of many common blood pressure medications results in upregulatation of ACE2 receptors. "Professor Esler’s original concerns were the blood pressure drugs ARBs, which can cause a five-fold increase in ACE2 expression."
As ACE2 is how covid docks into the cell, the assumption is that those with higher numbers of ACE2 receptors are prone to having worse outcomes following infection. Maybe the same is true following vaccination?
My blood pressure dramatically increased after taking the vaccine. To compensate I moved to a whole foods plant based diet, also now take 20mg Lisinopril each morning and run 20-25 miles per week. That routine keeps it in the normal range…if I deviate from that it starts climbing again.
"A supermajority of these cases had a history of pre-existing hypertension and majority were taking antihypertensives at the time of the vaccination."
This statement made me think of the Kryptonite Hypothesis: https://www.scientificdissent.com/the-kryptonite-hypothesis/.
According to this hypothesis, long term use of many common blood pressure medications results in upregulatation of ACE2 receptors. "Professor Esler’s original concerns were the blood pressure drugs ARBs, which can cause a five-fold increase in ACE2 expression."
As ACE2 is how covid docks into the cell, the assumption is that those with higher numbers of ACE2 receptors are prone to having worse outcomes following infection. Maybe the same is true following vaccination?
Thank you James, well done!
My blood pressure dramatically increased after taking the vaccine. To compensate I moved to a whole foods plant based diet, also now take 20mg Lisinopril each morning and run 20-25 miles per week. That routine keeps it in the normal range…if I deviate from that it starts climbing again.