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Covid is an ethnic bioweapon

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Covid is an ethnic bioweapon

One group’s ACE2 genetic variants decrease binding with the spike protein. (Updated 1/6/23)

James Hill, MD
Sep 8, 2021
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Covid is an ethnic bioweapon

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(I plan to update this article, as some links to scientific papers and tweets disappeared when Twitter suspended my account.)

One ethnic group has genetic variants most resistant to SARS-CoV-2 spike protein binding to ACE2 and TMPRSS2 receptors.

Ali et al.:

1

We combined ACE2 coding variants' analysis in different populations and computational chemistry calculations to probe the effects on SARS-CoV-2/ACE2 interaction.

ACE2-K26R; most frequent in Ashkenazi Jewish population decreased the SARS-CoV-2/ACE2 electrostatic attraction. On the contrary, ACE2-I468V, R219C, K341R, D206G, G211R increased the electrostatic attraction; ordered by binding strength from weakest to strongest. …

The aforementioned variants are most frequent in East Asian, South Asian, African and African American, European, European and South Asian populations, respectively.

Hou et al.:

2

We found that the distribution of deleterious variants in ACE2 differs among 9 populations in gnomAD (v3).

Specifically, 39% (24/61) and 54% (33/61) of deleterious variants in ACE2occur in African/African-American (AFR) and Non-Finnish European (EUR) populations, respectively.

Prevalence of deleterious variants among Latino/Admixed American (AMR), East Asian (EAS), Finnish (FIN), and South Asian (SAS) populations is 2–10%, while Amish (AMI) and Ashkenazi Jewish (ASJ) populations do not appear to carry such variants in ACE2 coding regions.

Specifically, several variants, including p.Met383Thr, p.Pro389His, and p.Asp427Tyr, have been reported to slightly inhibit the interaction between ACE2 and the spike protein of SARS-CoV-1, which caused the first global SARS-CoV-1 outbreak.

Only AFR populations carry p.Met383Thr and p.Asp427Tyr variants, with allele frequencies of 0.003% and 0.01%, respectively.

The p.Pro389His only occurs in the AMR populations, with an allele frequency of 0.015%.

The p.Arg514Gly is a low allele frequency (0.003%) variant in AFR populations and is also somatically mutated in colon cancers and melanomas from The Cancer Genome Atlas (TCGA: https://portal.gdc.cancer.gov).

Bakhshandeh et al.:

3

A study reported ACE2 variants in two populations, Caucasians and Asians, and their possible effect on SARS-CoV-2 infection Rojas et al. (2020).

Their results showed that two mutations have different frequencies in these two races, affecting ACE2 binding to spike protein.

In another study on ACE2 variants in different ethnicities, Lys26Arg mutation in Ashkenazi Jews reduced ACE2 affinity, in contrast to mutations in other populations, including East Asian (Ile468Val), South Asian (Arg219Cys), African and African American (Lys341Arg), European (Asp206Gly), European and South Asian (Gly211Arg) (Ali et al., 2020).

In an independent study, ACE2 genotypes in Africa and Eastern Mediterranean population were considered protective against COVID-19 (Karahalil and Elkama, 2020).

In a cohort of Russian patients infected by COVID-19, three rare variants (rs146598386, rs755766792, rs73195521) may affect SARS-CoV-2 infection outcome were found (Shikov et al., 2020).

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James Hill, MD @jhillmd
Twitter censored my prior tweet showing this graphic from the article below on ethnic vulnerability to the #COVID19 virus spike protein. ncbi.nlm.nih.gov/pmc/articles/P…
Image
4:48 PM ∙ Aug 12, 2021
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James Hill, MD @jhillmd
1/ Ethnic bioweapon? More on White people of European descent being targeted genetically by #COVID19, Jewish people relatively spared. Hou: “We found distribution of deleterious variants in ACE2 differs among 9 populations in gnomAD (v3). …”
bmcmedicine.biomedcentral.comNew insights into genetic susceptibility of COVID-19: an ACE2 and TMPRSS2 polymorphism analysis - BMC MedicineBackground Coronavirus Disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has now been confirmed worldwide. Yet, COVID-19 is strangely and tragically selective. Morbidity and mortality due to COVID19 rise dramatically with age and co-existing health …
9:58 AM ∙ Jun 10, 2021
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James Hill, MD @jhillmd
Which other ethnic groups have relative genetic resistance to #COVID19? Bakhshandeh: “In an independent study, ACE2 genotypes in Africa and Eastern Mediterranean population were considered protective against COVID-19.”
ncbi.nlm.nih.govVariants in ACE2; potential influences on virus infection and COVID-19 severityThe third pandemic of coronavirus infection, called COVID-19 disease, was first detected in November 2019th. Various determinants of disease progression such as age, sex, virus mutations, comorbidity, lifestyle, host immune response, and genetic background ...
2:00 AM ∙ Jun 9, 2021
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James Hill, MD @jhillmd
1/ One ethnic group most resistant to SARS-CoV-2 infection. Ali: “We combined ACE2 coding variants' analysis in different populations and computational chemistry calculations to probe the effects on SARS-CoV-2/ACE2 interaction.” …
ncbi.nlm.nih.govACE2 coding variants in different populations and their potential impact on SARS-CoV-2 binding affinityThe susceptibility of different populations to SARS-CoV-2 infection is not yet understood. Here, we combined ACE2 coding variants’ analysis in different populations and computational chemistry calculations to probe the effects on SARS-CoV-2/ACE2 interaction. ...
1:33 AM ∙ Jun 9, 2021
125Likes75Retweets

1

Ali F, Elserafy M, Alkordi MH, Amin M. ACE2 coding variants in different populations and their potential impact on SARS-CoV-2 binding affinity. Biochem Biophys Rep. 2020 Dec;24:100798.

2

Hou, Y., Zhao, J., Martin, W. et al. New insights into genetic susceptibility of COVID-19: an ACE2 and TMPRSS2 polymorphism analysis. BMC Med 18, 216 (2020).

3

Bakhshandeh B, Sorboni SG, Javanmard AR, Mottaghi SS, Mehrabi MR, Sorouri F, Abbasi A, Jahanafrooz Z. Variants in ACE2; potential influences on virus infection and COVID-19 severity. Infect Genet Evol. 2021 Jun;90:104773.

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Covid is an ethnic bioweapon

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Hermes
Jan 4·edited Jan 4Liked by James Hill, MD

From Ali et al.:

"The K26R variant which decreases the ACE2-virus binding was found to be most frequent in the Ashkenazi Jewish population (1.2%). "

I read: 1,2% of the jewish population has this mutation that mitigates disease from covid. Is that correct?

If this bioweapon was designed to not target jewish population, mitigation of disease for 1,2% of that population is not a big effect.

Hou finds a bigger difference:

"We found that the distribution of deleterious variants in ACE2 differs among 9 populations in gnomAD (v3). Specifically, 39% (24/61) and 54% (33/61) of deleterious variants in ACE2 occur in African/African-American (AFR) and Non-Finnish European (EUR) populations, respectively (Fig. 1b). Prevalence of deleterious variants among Latino/Admixed American (AMR), East Asian (EAS), Finnish (FIN), and South Asian (SAS) populations is 2–10%, while Amish (AMI) and Ashkenazi Jewish (ASJ) populations do not appear to carry such variants in ACE2 coding regions (Fig. 1b).”

But if this is a dark jewish setup, how come that in Israël they were the most fanatic with the vaccines?

And are there any signs that in the real world (and not computer models) this actually makes a difference?

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Potatodots
Oct 5, 2022Liked by James Hill, MD

FASCINATING.

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