Three features of a vaccine designed to breed deadlier viral variants, plus four features that can harm people differentially

Is it a coincidence Covid vaccines have these properties? (Updated 1/28/24)

If a bioweapon maker designed a vaccine optimally to evolve more lethal variants of a virus over time, what would the vaccine look like?

It would have three characteristics:

1. Single target antigen

   Using only one antigen in a vaccine provides easier immune escape by viral variants than if multiple antigens were used, such as with a whole virus vaccine.

   Current Covid vaccines, for instance, use the spike protein as a single antigen. Although the spike protein’s receptor binding domain (RBD) is indeed the most important antigenic region for generating neutralizing antibodies, it rapidly mutates and escapes vaccinal immunity.

   The viral membrane (M) protein, however, also appears to provoke a neutralizing antibody response and is more mutationally stable and therefore less likely to escape vaccinal immunity.

   Yet without explanation, makers of authorized vaccines have not included the M protein as a vaccine target or explained why.

2. Mass vaccination during rapid viral spread to accelerate evolution of immune-escape variants

   The high immune pressure created by vaccinating an entire population, together with the high infectious pressure of a virus spreading rapidly (e.g., during a pandemic), leads to rapid selection of variants evading vaccinal immunity.

3. Block illness substantially but not transmission or infection

   This reduces selection against more lethal variants and, according to Gandon et al., always leads to appearance of those deadlier variants.

   Covid vaccines do this.

If such a bioweapon vaccine were also aimed at hurting some people more than others, four more features might also be sought:

1. Uncontrolled dose

   Use mRNA or DNA (nucleic acids) to produce variable, uncontrollable amounts of the target antigen in people, rather than a specified dose as used in traditional protein vaccines.

   In this way, some vaccinated people produce a lot of the protein encoded by the vaccine, and others produce a little. This is likely one factor leading to wide variation in the incidence and severity of side effects.

2. Encode harmful parts of the virus

   Covid vaccines, for example, encode the full-length spike protein, without removing potentially dangerous amino acid sequence regions (epitopes) that can cause blood clotting, blood vessel inflammation, or autoimmunity.

3. Untraceable vials

   Forbidding serial numbers on vaccine vials or cartons could allow perpetrators to deliver deadlier vaccine doses to some people and not others without anyone being able to figure it out.

4. Secret batch sizes

   Vaccine lots (batches) contain differing numbers of doses and reported adverse events, but vaccine companies won’t reveal the number of doses in each batch.

   This makes it impossible to determine if rates of adverse events per batch differ, potentially allowing effects of more toxic batches to be hidden among effects of other, less harmful batches.

Remarkably, current Covid vaccines have all seven of these features.

Surely just a coincidence?